K teto cachi se vaze rozsahla diskuze na gc.cz. Kdo chce, muze se podivat zde (neni nutne k vylusteni). Vysledkem diskuze bylo, ze cache zmenila podobu, aby neslo jen o googleni. Snad jsme pro Vas pripravili zabavnejsi alternativni cestu k finalnim souradnicim. Diky tomu jsme snizili obtiznost o jeden bod.
Rybicka
od Evicky a Betaxe
Cesky / Czech
Na uvodnich souradnicich stoji FN Brno Detska nemocnice. Tam cache nehledejte! V Detske nemocnici v pavilonu G (na uvodnich souradnicich) se nachazi Oddeleni lekarske genetiky (OLG FN Brno). Ani tam cache nehledejte! Souvislost s OLG je dana tim, ze pujde o klasicke vedomostni lusteni (pro nektere googleni) zamerene na oblast GENETIKY.
Nasleduje 8 otazek formou testu a 8 spravnych odpovedi, ktere vas dovedou az k finalni small krabicce. Abyste nemuseli jenom googlit, pripravili jsme pro vas 7 ruzne koncipovanych hintu, ktere vam maji zprijemnit lusteni. Prejeme prijemne otevreni dveri a nakouknuti do oboru genetiky!
A: Ktery biochemicky marker se vyuziva pri prvotrimestralnim screeningu?
|
B: Screening nebalancovanych subtelomerovych zmen u pacientu s mentalni retardaci se provadi metodou
|
| a) AFP (alfa - 1 - fetoprotein) |
(A=0) |
| b) SP1 (trofoblast specificky beta 1 globulin) |
(A=1) |
| c) PAPP-A (pregnancy associated plasma protein A) |
(A=2) |
| d) uE3 (nekonjugovany estriol) |
(A=3) |
|
| a) RT - PCR |
(B=2) |
| b) G - pruhovani |
(B=4) |
| c) MLPA |
(B=6) |
| d) SSCP |
(B=8) |
|
| hint |
hint |
|
C: Mezi X-recesivne vazana onemocneni patri
|
D: Cim je zpusoben syndrom Wolf - Hirschhorn?
|
| a) cysticka fibroza |
(C=1) |
| b) Huntingtonova choroba |
(C=3) |
| c) hemofilie A a B |
(C=5) |
| d) neurofibromatosa |
(C=7) |
|
| a) nadbytecny chromozom 21 |
(D=1) |
| b) chybejici chromozom X |
(D=3) |
| c) Robertsonova translokace chromozomu 13 a 14 |
(D=5) |
| d) chybejici kratke ramenko chromozomu 4 |
(D=7) |
|
| hint |
hint |
|
E: Ktere onemocneni nepatri mezi tzv. TREDs?
|
F: Mezi degenerativni stigmata obliceje a hlavy nepatri
|
| a) Alzheimerova choroba |
(E=6) |
| b) Huntingtonova choroba |
(E=7) |
| c) Myotonicka dystrofie typu 1 |
(E=8) |
| d) Syndrom Fragilniho X |
(E=9) |
|
| a) hypertelorismus |
(F=2) |
| b) epicanthy |
(F=4) |
| c) dysplasticke usni boltce |
(F=6) |
| d) polydaktylie |
(F=8) |
|
| hint |
hint |
|
G: Mezi mikrodelecni syndromy patri
|
H: Proc se tato cache jmenuje Rybicka?
|
| a) Downuv syndrom |
(G=1) |
| b) Patauuv syndrom |
(G=2) |
| c) Wolf-Hirshorn |
(G=3) |
| d) Angelman syndrom |
(G=4) |
|
| a) protoze autorovo hobby je akvaristika |
(H=6) |
| b) protoze na OLG Brno v laboratori u mikroskopu je akvarium s rybickami |
(H=7) |
| c) protoze je to nazev jedne z molekularne - cytogenetickych metod |
(H=8) |
| d) protoze autor chce touto cestou pouze zmast geocachery-lustitele |
(H=9) |
|
| hint (mejte strpeni pri nacitani) |
hint neni... :) |
Cache:
Krabicka se nachazi na souradnicich: N 49° 1A.BCD, E 016° 3E.FGH. Cache je lock & lock velikosti small. Abyste se nehonili po celem Brne, mame pro Vas verifikator. :) Pri zalozeni obsahovala cache par laboratornich pomucek. Prosim, nevkladejte zadny geoodpad! Cache se nenachazi v arealu Mendelovy Univerzity!! Prejeme prijemny lov!
You can check your answers for this puzzle on GeoChecker.com.
Anglicky / English
The Children's Medical Center at The University Hospital Brno is located on the start´s coordinates. Don´t look for the cache there! There is only The Department of Medical Genetics (OLG FN Brno). This cache is about GENETICS. There are 8 test questions and 8 right answers. They give you the right way to the final cachebox. I wish good luck with the questions!
A: The first trimester screening in pregnancy - which hormon is detected?
|
B: Which of these methods is used for screening for subtelomeric rearrangement in patients with unexplained mental retardation?
|
| a) AFP |
(A=0) |
| b) SP1 |
(A=1) |
| c) PAPP-A |
(A=2) |
| d) uE3 |
(A=3) |
|
| a) RT - PCR |
(B=2) |
| b) G – banding |
(B=4) |
| c) MLPA |
(B=6) |
| d) SSCP |
(B=8) |
|
|
H: Which of these desease is X-linked recessive disease?
|
D: Which chromosomal aberration is the cause of microdeletion Wolf-Hirschhorn syndrome?
|
| a) Cystic fibrosis |
(C=1) |
| b) Huntington's disease |
(C=3) |
| c) Haemophilia A and B |
(C=5) |
| d) Neurofibromatosis |
(C=7) |
|
| a) trisomy 21 |
(D=1) |
| b) monosomy X |
(D=3) |
| c) Robertsonian translocation between chromosomes 13 and 14 |
(D=5) |
| d) deletion 4p |
(D=7) |
|
|
E: Which disease is not the TREDs desease?
|
F: Which of the dysmorphic features are not the stigmata on the face and head
|
| a) Alzheimer's disease |
(E=6) |
| b) Huntington's disease |
(E=7) |
| c) Myotonic dystrophy type 1 |
(E=8) |
| d) Fragile X syndrome |
(E=9) |
|
| a) hypertelorism |
(F=2) |
| b) epicanthus |
(F=4) |
| c) dysplastic ears |
(F=6) |
| d) polydactyly |
(F=8) |
|
|
G: Which of these syndromes is the microdeletion syndrome?
|
H: Why is the name of this cache The FISH?
|
| a) Down syndrome |
(G=1) |
| b) Patau syndrome |
(G=2) |
| c) Wolf-Hirshorn syndrome |
(G=3) |
| d) Angelman syndrome |
(G=4) |
|
| a) Because author likes aquarium |
(H=6) |
| b) Because at The laboratory is an aquarium with fishes |
(H=7) |
| c) Because it is the name of some molecular cytogenetic method |
(H=8) |
| d) Because author wants to confuse the cachers |
(H=9) |
|
|
Cache:
The final cache is located on the coordinates: N 49° 1A.BCD, E016° 3E.FGH. Cache is the box lock & lock of small size. The cache isn´t inside the campus of Mendel University in Brno. Good hunt!
You can check your answers for this puzzle on GeoChecker.com.