Thames and Medway Canal
This isn't too difficult, all the information you need to get you started is on this page and once you are on the right track you should be able to google the answers.
The cache can be found somewhere along the canal and can be accessed from the National Cycle route that runs parallel to it. This is a permissive path, owing to the police shooting range found just off the path, so you may need to come in from another angle if the red flags are up.
Not particularly dangerous, but you attempt this at your own risk.
To discover the coordinates you'll need to work out the following:
N51 xx.xxx
Portishead to Portland Bill
Land's End to Bristol
Cardiff to Holyhead
Belfast to Dublin
E000 xx.xxx
Bath to Eastleigh
Reading to Holyhead
Llanwrtyd Wells to Pontrhydfendigaid
Magnetic Nano
You can check your answers for this puzzle on Geochecker.com.